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Aging changes in immunity


Your immune system helps protect your body from foreign or harmful substances. Examples are bacteria, viruses, toxins, cancer cells, and blood or tissues from another person. The immune system makes cells and antibodies that destroy these harmful substances.

Aging Changes and Their Effects on the Immune System

As you grow older, your immune system does not work as well. The following immune system changes may occur:

  • The immune system becomes slower to respond. This increases your risk of getting sick. Flu shots or other vaccines may not work as well or protect you for as long as expected.
  • An autoimmune disorder may develop. This is a disease in which the immune system mistakenly attacks and destroys healthy body tissues.
  • Your body may heal more slowly. There are fewer immune cells in the body to bring about healing.
  • The immune system's ability to detect and correct cell defects also declines. This can result in an increased risk of cancer.


To decrease the risks from immune system aging:

  • Get the flu and pneumonia vaccines, and any other vaccines your health care provider recommends.
  • Get plenty of exercise. Exercise helps boost your immune system.
  • Eat healthy foods. Good nutrition keeps your immune system strong.
  • DO NOT smoke. Smoking weakens your immune system.
  • Limit your intake of alcohol. Ask your provider how much alcohol is safe for you.
  • Look into safety measures to prevent falls and injuries. A weak immune system can slow healing.

As You Grow Older, You Will Have Other Changes, Including in Your:


Hall WJ, Ahmed B. Pulmonary disorders. In: Duthie EH, Katz PR, Malone ML, eds. Practice of Geriatrics. 4th ed. Philadelphia, PA: Elsevier Mosby; 2007:564.

McDevitt MA. Aging and the blood. In: Fillit HM, Rockwood K, Woodhouse K, eds. Brocklehurst's Textbook of Geriatric Medicine and Gerontology. 7th ed. Philadelphia PA: Elsevier Saunders; 2010:chap 21.

Minaker KL. Common clinical sequelae of aging. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 24.

Tummala MK, Taub DT, Ershler WB. Clinical Immunology: Immune senescence and the acquired immune deficiency of aging. In: Fillit HM, Rockwood K, Woodhouse K, eds. Brocklehurst's Textbook of Geriatric Medicine and Gerontology. 7th ed. Philadelphia PA: Elsevier Saunders; 2010:chap 13.

Review Date: 10/27/2014
Reviewed By: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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