Neurosyphilis is a bacterial infection of the brain or spinal cord. It usually occurs in people who have had untreated syphilis for many years.
Neurosyphilis is caused by Treponema pallidum. This is the bacteria that causes syphilis. It usually occurs about 10 to 20 years after a person is first infected with syphilis. Not everyone who has syphilis develops this complication.
The antibiotic penicillin is used to treat neurosyphilis. It can be given in different ways:
Injected into a vein several times a day for 10 to 14 days.
By mouth 4 times a day, combined with daily muscle injections, both taken for 10 to 14 days.
You must have follow-up blood tests at 3, 6, 12, 24, and 36 months to make sure the infection is gone. You will need follow-up lumbar punctures for CSF fluid analysis every 6 months. If you have HIV/AIDS or another medical condition, your follow-up schedule may be different.
Neurosyphilis is a life-threatening complication of syphilis. How well you do depends on how severe the neurosyphilis is before treatment.
The symptoms can slowly worsen.
When to Contact a Medical Professional
Call for an appointment with your health care provider if you have had syphilis in the past and now have signs of nervous system problems.
Prompt diagnosis and treatment of the original syphilis infection can prevent neurosyphilis.
Radolf JD, Tramont EC, Salazar JC. Syphilis (Treponema pallidum). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 239.
Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.